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Inducers of CYP3A4 The concomitant usage of PERCOCET and CYP3A4 inducers, which include rifampin, carbamazepine, and phenytoin, can reduce the plasma focus of oxycodone [see scientific PHARMACOLOGY], causing lowered efficacy or onset of the withdrawal syndrome in individuals who have created physical dependence to PERCOCET [see WARNINGS]. Infants